Prior to bedtime, participants were shown photo pairings of 25 animals and celebrities. READ MORE: Early-Stage Findings of Ketogenic Agent CER-0001 in Infantile Spasms Warrant Further Investigation As noted in a statement from Fried, the system “listened” to the brain’s electrical signals, and when once patients fell into deep sleep, it gave gentle electrical pulses telling the rapidly firing neurons to “play” in synchronization. Researchers developed a real-time closed-loop system to deliver electrical stimulation to the participants. Electrodes were implanted in the patients to help with identifying the source of their seizures during their hospital stays, which typically lasted around the span of 10 days. Led by author Maya Geva-Sagiv, PhD, postdoctoral research fellow, University of California, Davis, and colleagues, memory consolidation during sleep was investigated via electrodes in patients with epilepsy recruited from UCLA Health. 1 “It has both scientific value in terms of understanding how memory works in humans and using that knowledge to really boost memory.” “This provides the first major evidence down to the level of single neurons that there is indeed this mechanism of interaction between the memory hub and the entire cortex,” coauthor Itzhak Fried, MD, PhD, director of epilepsy surgery at University of California, Los Angeles (UCLA) Health said in a statement. Notably, the key electrophysiological markers displayed the flow of information between the hippocampus and throughout the cortex, which provided evidence to support memory consolidation. 2Īmong 18 patients with epilepsy assessed across 2 nights and mornings, each one performed better on the memory tests given following a night of sleep and the use of electrical stimulation in their brain compared with a night of undisturbed sleep. 1 These findings provide evidence to support how the brain consolidates memory during sleep and offer new clues for how deep-brain stimulation during sleep could help patients with memory disorders like Alzheimer disease. In a recent study published in Nature Neuroscience, findings revealed that targeted deep-brain stimulation during a critical time in the sleep cycle was associated with improvements in memory consolidation among patients with epilepsy.
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